Abstract
We present the comparative study of plasma chromogranin A (CgA) levels measured in 232 patients with different types of neuroendocrine tumors (NETs) and 66 healthy individuals using enzyme immunoassay Chromogranin A ELISA kit (Dako). CgA levels were significantly higher in patients with all types of NETs than in healthy subjects. CgA secretion were highly variable. The study demonstrate high diagnostic sensitivity of CgA, which was 80.6 % in overall group of NETs with specificity 98.5 %. We confirmed the prognostic significance of CgA, in this case the high basal levels of CgA (above 100 U/l) were significantly associated with less favorable prognosis of progression free survival after different types of treatment. The data confirms high efficiency of CgA as biomarker, which measurement enhances the accuracy of diagnosis and prognosis of NETs.
Highlights
Summary We present the comparative study of plasma chromogranin A (CgA) levels measured in 232 patients with different types of neuroendocrine tumors (NETs) and 66 healthy individuals using enzyme immunoassay Chromogranin A ELISA kit (Dako)
CgA levels were significantly higher in patients with all types of NETs than in healthy subjects
We confirmed the prognostic significance of CgA, in this case the high basal levels of CgA were significantly associated with less favorable prognosis of progression free survival after different types of treatment
Summary
Резюме Представлены результаты сравнительного исследования хромогранина А (ХгА) в плазме крови 232 больных нейроэндокринными опухолями (НЭО) и 66 практически здоровых мужчин и женщин при использовании стандартизованного иммуноферментного метода в плашечном формате на основе тест-системы Chromogranin A ELISA kit (Dako). Продемонстрирована высокая диагностическая чувствительность ХгА, которая в целом по группе больных НЭО составила 80,6 % при специфичности 98,5 %. Подтверждено прогностическое значение ХгА, при этом высокие базальные уровни ХгА (более 100 Ед/л) достоверно связаны с менее благоприятным прогнозом выживаемости без прогрессирования при различных схемах лечения.
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