Abstract
Experimental allergic arthritis in guinea pig has been investigated as a model of immunosynovitis. The course of synovial injury and recovery is quantitatively estimated by microscopic and autoradiographic evaluation. Using 3-H-thymidine pulse and prelabeling techniques it has been shown, that bone marrow derived monocyte-macrophage cells play a major role in the histopathogenesis of this form of arthritis. Cell kinetic studies during the initiation of experimental synovitis support the hypothesis, that so-called lining cell hyperplasia is predominantly due to infiltration by blood monocytes, which during the stage of recovery contribute to a secondary lining cell layer. The early bone and cartilage erosions are additional lesions, which appear to be dependent on the monocyte-macrophage system.
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