Abstract

Introduction: Angiogenesis is a complex event mediated by several angiogenic factors released from cancer cells and immune cells. There is compelling evidence that mast cell accumulation among the peritumoral inflammatory infiltrates contributes to a favourable microenvironment for tumor development and metastasis. The present study aimed to evaluate the relationship between mast cells and microvessels by applying the double staining CD34/toluidine blue in cutaneous malignancies. Materials and Methods: The study consisted of 50 cases of cutaneous malignancies. Combined Immunohistochemical and Histochemical methods used to study the microvessels and mast cells. Results: A significant correlation between the mast cell count and microvessel density was observed in all 3 cutaneous malignancies. Statistical analysis of the linear correlation between MCD and MVD was also performed (P

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.