Abstract

The extra-cellular matrix of connective tissues is a composite material containing a hydrated proteoglycan-rich (PG) gel reinforced by collagen fibrils. We review recent studies at micro and nano-length scale of the structure of ECMs in connective tissues that have yielded insights into molecular mechanisms influencing the material properties during tissue growth, maturation and old-age. These insights could provide further understandings for current studies addressing (1) tissue injury and repair mechanisms and (2) biological compatibility of implant materials in the context of age.KeywordsAgeingcollagenproteoglycansstructurematerial properties

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