Significance changes in the levels of myocardial enzyme in the child patients with Mycoplasma Pneumoniae Pneumonia

Xueliang Qi,Xuemin Li,Dejin Kong,Xiangguo Sun,Luhua Zhao

doi:10.14715/cmb/2020.66.6.8

Abstract

Mycoplasma is a gram-negative with thin wall bacterium that in humans, Mycoplasma pneumoniae causes pneumonia. This experiment was designed to explore the changes of myocardial enzymes in the mycoplasma pneumoniae pneumonia (MPP) child patients, and analyze the clinical value of these changes, in combination with the relevant indicators, symptoms and signs, in the evaluation of the pneumonia mycoplasma infection. For this aim, a total of 120 child patients with MPP in the acute phase,120 child patients with MPP in the recovery phase and 120 healthy children were simultaneously enrolled into this study to detect the levels of aspartate aminotransferase (AST), creatine kinase (CK), Creatine Kinase Isoenzyme (CK-MB) and lactic dehydrogenase (LDH) in blood. Results showed that MPP patients in the acute phase had higher levels of LDH, CK, CK-MB, AST, PCt, CRP, MPV, PDW, PCt, percentage of neutrophils, WBC count in the peripheral blood and ESR than those of the patients in the recovery patients and healthy children, while the level of PLT was lower (all P<0.05). In the acute phase, the level of CK-MB correlated to the fever, fever duration, extrapulmonary organ damage (except for the myocardial damage) and the antibody titer of MP (all P<0.05). It was concluded that in the acute phase of MMP, the level of CK-MB could not only reflect the myocardial damage readily but also the infection of MP as well as the resultant inflammation and disease progression, which could effectively guide the diagnosis and treatment of MPP.

Highlights

Mycoplasma pneumoniae (MP) has gradually become the major cause of pediatric pneumonia
Results showed that mycoplasma pneumoniae pneumonia (MPP) patients in the acute phase had higher levels of lactic dehydrogenase (LDH), creatine kinase (CK), CK-MB, AST, PCt, C-reactive protein (CRP), mean platelet volume (MPV), platelet distribution width (PDW), PCt, percentage of neutrophils, white blood cells (WBCs) count in the peripheral blood and erythrocyte sedimentation rate (ESR) than those of the patients in the recovery patients and healthy children, while the level of PLT was lower
Subjects A total of 120 child patients with MPP in the acute phase, consisting of 69 males and 51 females aged between 2 months and 12 years old with an average of (5.77±1.44) years old, 120 child patients with MPP in the recovery phase, consisting of 67 males and 53 females aged between 2 months and 12 years old with an average of (5.47±1.56) years old, and 120 healthy children, consisting of 66 males and 54 females aged between 2 months and 12 years old with an average of (5.85±1.57) years old were simultaneously enrolled into this study

Summary

Introduction

Mycoplasma pneumoniae (MP) has gradually become the major cause of pediatric pneumonia. According to a large-scale survey, among the in-hospital pediatric patients aged 5 years old or below, MP infection has taken up nearly 29.01% [1]. Mycoplasma pneumoniae pneumonia (MPP) occurs mostly in the school-age children, resulting in the damage to the gastrointestinal, cardiac and urinary systems of the patients and threatening the mental and physical health of the children [2]. A study shows that among the extrapulmonary complications of MPP, the involvement of cardiovascular disease occupies almost 27.91% of the patients [3]. Factors of myocardial damage are significant for the early diagnosis and prophylaxis of cardiac complications. We aimed to explore the clinical value of CK-MB, as the indicator of myocardial damage in MPP pediatric patients, in combination with the relevant indicators, symptoms and signs, in treatment of the MP infection

Objectives

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Results

Conclusion