Abstract
Signet ring B cell lymphoma is an unusual non-Hodgkin lymphoma. It is similar to signet ring cell carcinoma and liposarcoma in morphology which should be distinguished. We treated a 63-year-old male patient who suffered from abdominal pain for two months. Multiple enlarged lymph nodes were found in the retroperitoneum by CT scan. The needle biopsy showed neoplastic cells distributed uniformly with clear cytoplasm and the nucleus squeezed to the side mimicking the appearance of signet ring in morphology. By special staining, the neoplastic cells were positive for CD45, Vimentin, Bcl-2 and CD20 but negative for AE1/AE3, S-100, CD3, EMA, CD5, CD10, Bcl-6, MUM1 , Kappa, Lambda and PAS . Ki67 proliferation index was much more than 80%. Based on the histological characters, a diagnosis of signet ring B cell lymphoma was made. Although the patient received six courses of R-CHOP therapy, he died of tumor recurrence at the 34th month after diagnosis.
Highlights
Signet ring B cell lymphoma is an unusual non-Hodgkin lymphoma
Signet ring cell lymphoma is a rare type of non-Hodgkin lymphoma, in which the tumor nucleus is on the side of the cell, just like a signet ring, in morphology [1]
The initial goal should be to eliminate metastasis of the signet ring cell from gastrointestinal tract and liposarcoma [3,4]. This is due to lymph node metastasis being more common than the signet ring cell lymphoma, but it is more important to judge the origin of tumor correctly
Summary
Abstract: Signet ring B cell lymphoma is an unusual non-Hodgkin lymphoma. The needle biopsy showed neoplastic cells distributed uniformly with clear cytoplasm and the nucleus squeezed to the side mimicking the appearance of signet ring in morphology. Based on the histological characters, a diagnosis of signet ring B cell lymphoma was made. The patient received six courses of R-CHOP therapy, he died of tumor recurrence at the 34th month after diagnosis. Signet ring cell lymphoma is a rare type of non-Hodgkin lymphoma, in which the tumor nucleus is on the side of the cell, just like a signet ring, in morphology [1]. The biological behavior and clinical manifestations of signet ring B cell lymphoma might be similar to the lymphoma originating from the germinal center. The clinic-pathological features of the case were provided and much attention should be paid by pathologists and hematologist during the diagnosis
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