Abstract
Comparison of the gene expression in human T regulatory cells and naïve cells using a T regulatory cell-specific microarray reveals cell-specific gene signatures.
Highlights
Occurring CD4+CD25+ regulatory T cells (TReg) are involved in the control of autoimmune diseases, transplantation tolerance, and anti-tumor immunity
Different CD4+CD25- derived Th cell lines were generated by infection with retroviruses encoding for FOXP3 and GFP under the control of an internal ribosomal entry side (IRES) or with an empty control vector that contained only GFP
We found 18 genes in our human TReg cell signature that have been reported to contribute to pathogenesis of this disease, including granzyme A (GZMA) [63], the CD40 ligand (TNFSF5) [64,65], CTLA4 [66], and the T-cell specific transcription factor 7 (TCF7) [67]
Summary
Occurring CD4+CD25+ regulatory T cells (TReg) are involved in the control of autoimmune diseases, transplantation tolerance, and anti-tumor immunity. Self-reactive T cells are deleted during their development in the thymus in a process known as central tolerance. Because this negative selection is incomplete, self-reactive T cells that have escaped from this clonal deletion must be controlled in the periphery. TReg cells actively suppress activation and expansion of self-reactive escapees as part of a process termed peripheral tolerance [1]. TReg cells control the delicate balance between immunity and tolerance, explaining their important role in autoimmune diseases, cancer, transplantation tolerance, and even allergy
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