Abstract

Endometrial milk fat globule EGF factor 8 (MFG-E8) has been discovered and studied by our group with predominant localization in the epithelium during the window of implantation. Our recent findings have shown that dysregulated MFG-E8 impairs endometrial receptivity and embryo attachment. This protein is traditionally thought to play a role in promoting tumor cell invasion, metastasis and angiogenesis. However, it is not known whether MFG-E8 regulates angiogenesis in the endometrium. Thus, we sought to determine the function of MFG-E8 on human endometrial endothelial cells (HEEC), hypothesizing that activation of the MFG-E8 production would stimulate angiogenesis.

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