Abstract
The recognition of pathogens through pattern recognition receptors (PRRs) and mediation of intracellular signal transduction by dendritic cells (DCs) are essential for the induction of adaptive immunity.It has been evidenced that C-type lectins are important PRRs that recognize carbohydrate structures.Most pathogens and allergens are rich in carbohydrate structures on their surface and these structures function as socalled sugar fingerprints which can be recognized by specific C-type lectins.After triggered through C-type lectins,DCs induce signaling cascades that subsequently initiate or modulate specific cytokine responses and therefore tailor T cell polarization to the pathogens.Here the authors introduce some common innate signaling pathways mediated by C-type lectins and how these pathways shape adaptive immunity. Key words: Signal transduction; Lectins,C-type
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