Abstract
Supramolecular clustering of receptors in the tumor necrosis superfamily, including tumor necrosis factor receptor 1 (TNFR1), Fas and Death Receptor 5 (DR5) has emerged as a potentially powerful paradigm shift in the field of apoptotic signaling. The canonical view of one ligand-one receptor is giving way to a revised picture of activity-dependent receptor aggregation. However, whether clusters have a specific structural organization stabilized by specific protein-protein contacts, as opposed to non-specific aggregation, remains unknown.
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