Abstract
Normally, the activated protein C has a protective role in sepsis, but the mechanism has not been known. Riewald et al. find that the thrombin receptor (protease activated receptor, or PAR1) is the target for activated protein C signaling. This mechanism provides insights into the signaling pathway of immune modulatory chemokines that control the host defense system in sepsis. M. Riewald, R. J. Petrovan, A. Donner, B. M. Mueller, W. Ruf, Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science 296 , 1880-1882 (2002). [Abstract] [Full Text]
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