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Abstract
Signaling from Within: Endocytic Trafficking of the Robo Receptor Is Required for Midline Axon Repulsion.
Highlights
Endocytosis of axon guidance receptors has previously been shown to modulate axon guidance receptor activity and signaling
Current models often depict that ligand binding to its receptor at the surface of the growth cone leads to the activation of the receptor, recruitment, and/or activation of signaling molecules near the cytoplasmic tail of the receptor, resulting in local signaling emanating from the subcellular compartment where the receptor was located upon binding of its ligand (Fig 1a)
An article by Chance and Bashaw, published in this issue of PLOS Genetics, uses complementary in vivo and in vitro experiments to challenge this view and show that endocytosis of the Roundabout (Robo) receptor is a key component of receptor activation and precedes the recruitment of its effectors to the receptor cytoplasmic domain [1]
Summary
Endocytosis of axon guidance receptors has previously been shown to modulate axon guidance receptor activity and signaling. An article by Chance and Bashaw, published in this issue of PLOS Genetics, uses complementary in vivo and in vitro experiments to challenge this view and show that endocytosis of the Roundabout (Robo) receptor is a key component of receptor activation and precedes the recruitment of its effectors to the receptor cytoplasmic domain [1]. In both invertebrates and vertebrates, Robo receptors comprise a family of axon guidance receptors that mediate repulsion in response to their Slit ligands.
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