Abstract
Insulin stimulates cell proliferation and suppresses hepatitis B surface antigen production in human hepatoma Hep3B cells through its own receptors. In order to elucidate the signal transduction pathway of insulin receptor on human hepatoma cells, we took three approaches: One, using long term treatment of phorbol ester to down regulate intracellular PKC, Two, using lovastatin to inactivate Ras protein’s activity. Third, overexpressing Rap1A protein which antagonize Ras protein’s activity in vivo to test the involvement of PKC and Ras protein in the signal transduction pathway of insulin on human hepatoma Hep3B cells. I will present data from my laboratory and discuss recent developments in this field.
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