Abstract

The mammalian olfactory system exhibits a highly complex organization that comprises several anatomically segregated chemoreceptive organs including the main olfactory epithelium (MOE), the vomeronasal organ (VNO), the septal organ (SO), the necklace neurons and the Grueneberg ganglion (GGN). Each of these organs contains functionally distinct groups of sensory neurons, or olfactory subsystems, that are differentiated based on their signal transduction mechanisms, the chemosensory cues they detect, and the axonal connections they establish to target specific regions in the olfactory bulb. In the present review, I will focus on the signaling mechanisms of the different cellular subtypes in mammals.

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