Abstract
It is well known that the immune response is decreased with aging leading to a higher susceptibility to infections, cancers and autoimmune disorders. The most widely studied alterations are relative to the adaptive immune response. Recently, the role of the innate immune response as first line of defence against bacterial invasion and modulator of the adaptive immune response has been widely recognized. One of the most important cell components of the innate response is neutrophils. It is now accepted that neutrophil functions are changed with age however the degree of these changes is still debated. With aging there is an alteration of the receptor driven functions of human neutrophils, such as superoxide anion production, chemotaxis and apoptosis. One of the alterations underlying these functional changes is the decrease of the receptor signalling elicited by specific receptors. Alterations were also found in the neutrophil membrane lipid rafts. These alterations in neutrophils functions and signal transduction occurring with aging might contribute to the increased infections with aging.
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