Signal transducer and activator of transcription 5 (STAT5) expression and activation in pancreatic cancer

Abstract

s / Pancreatology 13 (2013) e1–e94 e53 of the mouse pancreas via laparotomy. Two weeks post-cancer cell injection, a second laparotomy was performed to inject drug-loaded MPs or saline into the same tail section of the pancreas. Mouse tissue samples were taken to evaluate the local effects of constant drug release on the pancreatic tumors and to determine the extent of drug escape to the spleen and liver. Positive results of these combined studies will justify additional pre-clinical investigation in a transgenic mouse model of pancreatic cancer.