Abstract
Split-spectrum amplitude-decorrelation angiography (SSADA) is a noninvasive and three-dimensional angiographic technique with a microscale spatial resolution based on optical coherence tomography. The SSADA signal is known to be correlated with the blood flow velocity and the quantitative velocimetry with SSADA has been expected; however, the signal properties of SSADA are not completely understood due to lack of comprehensive investigations of parameters related to SSADA signals. In this study, phantom experiments were performed to comprehensively investigate the relation of SSADA signals with flow velocities, time separations, particle concentrations, signal-to-noise ratios, beam spot sizes, and viscosities, and revealed that SSADA signals reflect the spatial commonality within a coherence volume between adjacent A-scans.
Highlights
Optical coherence tomography (OCT) is an imaging technique to visualize three-dimensional structures of biomedical tissues, by means of low coherent interferometry of broadband infrared light [1,2,3,4,5,6]
To understand signal properties of Split-spectrum amplitude-decorrelation angiography (SSADA) and to realize quantitative velocimetry based on SSADA, we comprehensively investigated parameters related to SSADA signals with one OCT system
We examined the dependence of particle concentrations on SSADA signals, which correspond to the dependence of the hematocrit level, by using IL solutions with four different concentrations, 0.5, 1.0, 2.0, and 4.0%
Summary
Optical coherence tomography (OCT) is an imaging technique to visualize three-dimensional structures of biomedical tissues, by means of low coherent interferometry of broadband infrared light [1,2,3,4,5,6]. Doppler OCT (DOCT) [7,8,9], which quantifies the blood flow velocity within the tissue, is one of the functional imaging techniques that has been studied in the early stage after the establishment of OCT [9]. DOCT detects Doppler shift frequencies due to blood flows along the optical axis (axial direction) and has been applied in manifold fields such as retina and skin [7,8]. Its application is limited because Doppler shift frequencies are highly related to the angle between the incident light beam and vessel orientations. The retina has many blood vessels running perpendicular to the incident light beam, large amounts of blood vessels are unable to be detected by DOCT
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