Abstract
Environmental stresses have driven plants to develop various mechanisms to acclimate in adverse conditions. Extensive studies have demonstrated that a significant reprogramming occurs in the plant transcriptome in response to biotic and abiotic stresses. The highly conserved and large multi-subunit transcriptional co-activator of eukaryotes, known as the Mediator, has been reported to play a substantial role in the regulation of important genes that help plants respond to environmental perturbances. CDK8 module is a relatively new component of the Mediator complex that has been shown to contribute to plants’ defense, development, and stress responses. Previous studies reported that CDK8 module predominantly acts as a transcriptional repressor in eukaryotic cells by reversibly associating with core Mediator. However, growing evidence has demonstrated that depending on the type of biotic and abiotic stress, the CDK8 module may perform a contrasting regulatory role. This review will summarize the current knowledge of CDK8 module as well as other previously documented Mediator subunits in plant cell signaling under stress conditions.
Highlights
In order to perceive and respond effectively to environmental stresses, plants have developed sophisticated signaling transduction pathways that induce gene expression changes via a complex network of transcription factors (TFs)
The time when thesefor subunits knownasfor their in abiotic these defense At genes are responsible cuticlewere formation well as involvement for the biosynthesis stress responses, the function of
Other defense genes are related to pathogenesis
Summary
In order to perceive and respond effectively to environmental stresses, plants have developed sophisticated signaling transduction pathways that induce gene expression changes via a complex network of transcription factors (TFs). The CDK8 subunit is capable of recruiting different TFs to RNA Pol II to regulate multiple signaling pathways in yeast and eukaryotic cells including plant cells [15]. Evidence that supports the positive regulatory roles of CDK8 module has been indicated to contribute in drought stress regulation recently. The subunits of MED12 and MED13 were immune responses, Arabidopsis CDK8 was reported to perform a contrasting regulatory reported recently to serve as conditional positive gene regulators in Arabidopsis [12,13,14].
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