Abstract
Abstract A hybridization chain reaction (HCR) using a serinol nucleic acid (SNA) scaffold was newly designed and optimized. We found that hairpins with 8- or 9-mer loops, toeholds, and stems activated HCR and that the SNA interface accelerated initiation of HCR. Use of nitromethyl red as a quencher on the hairpin enabled detection of target RNA with high sensitivity. This system will be applicable to RNA detection in cell and biopsy, due to the high enzymatic durability of SNA.
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