Abstract
Methods Peanut allergic adults (n=94) and children (n=100) with a suspected peanut allergy were included. sIgE levels were measured by ImmunoCAP (Uppsala, Sweden). In all subjects the adapted Mueller score was used with one additional category for no symptoms (0-5): 0; no symptoms/peanut tolerant, 1; oral allergy symptoms, 2; cutaneous/mucosal symptoms, 3; gastrointestinal symptoms, 4; respiratory symptoms, 5; cardiovascular symptoms. A severe reaction was defined as a Mueller score of 4 or 5. Univariate and multivariate logistic regression analysis was used to calculate odds ratio’s.
Highlights
Many recent studies have shown the superior diagnostic accuracy of specific IgE to Ara h 2 compared to sIgE to peanut extract in diagnosing peanut allergy
Open Access sIgE to peanut components does not accurately predict the severity of allergy in subjects suspected of peanut allergy
The AUC values of sIgE to Ara h 2 and sIgE to peanut extract in the adult population were 0.81 and 0.70, respectively (compared to 0.77 (0.64-0.89) and 0.69 (0.53-0.85) in the pediatric population)
Summary
The aim of this study was to analyze the association between severity and sensitization levels
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