Si-Doped Carbon Quantum Dots: A Facile and General Preparation Strategy, Bioimaging Application, and Multifunctional Sensor

Abstract

Heteroatom doping of carbon quantum dots not only enables great improvement of fluorescence efficiency and tunability of fluorescence emission, but also provides active sites in carbon dots to broaden their application in sensor. Silicon as a biocompatible element offers a promising direction for doping of carbon quantum dots. Si-doped carbon quantum dots (SiCQDs) were synthesized through a facile and effective approach. The as-prepared Si-doped carbon quantum dots possess visible fluorescence with high quantum yield up to 19.2%, owing to fluorescence enhancement effect of introduced silicon atoms into carbon dots. The toxicity test on human Hela cells showed that SiCQDs have lower cellular toxicity than common CQDs, and bioimaging experiments clearly demonstrated their excellent biolabelling ability and outstanding performance in resistance to photobleaching. Strong fluorescence quenching effect of Fe(III) on SiCQDs can be used for its selective detection among general metal ions. Specific electron transfer between SiCQDs and hydrogen peroxide enables SiCQDs as a sensitive fluorescence sensing platform for hydrogen peroxide. The subsequent fluorescence recovery induced by removal of hydrogen peroxide from SiCQDs due to formation of the stable adducts between hydrogen peroxide and melamine was taken advantage of to construct effective sensor for melamine.