Abstract
2-cyanocrylic acid is the key intermediate for preparation of numerous classes of chemical substances for medical application. It opens new opportunities for preparation of novel esters which can't be prepared by standard method based on Knoevenagel condensation. 2-Cyanocrylic acid was prepared by modified scheme of vacuum pyrolysis of its ethyl ester. Obtained products were analyzed by 1H, 13C NMR and MALDI-TOF mass spectrometry. The modified scheme allowed to increase significantly the purity and yield of the target product, which reach 90% of the theoretically possible. By X-ray analysis of crystals of 2-cyanocrylic acid accompanied with MALDI-TOF mass spectrometry it has been proved that main side reaction reducing yield is formation of dimer by intermolecular Ritter condensation rather than polymerization of CC double bond of 2-cyanoacrylic acid as it was considered earlier.
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