Abstract
Electrophilic substitutions on aromatics such as C6H5X often lead to mixtures of the ortho- and para-disubstituted products C6H4XY. The former can chelate a metallic center and hence be a potential catalyst inactivator, whenever the (X, Y) substituents have atoms with lone pairs. This general principle operates in the Friedel-Crafts acylation of anisole, a reaction of industrial importance.
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