Abstract
BackgroundSide alternating vibration training (SAVT) is a mechanical oscillation using a vibrating platform that simulates exercise. We hypothesized that patients with mitochondrial myopathies, who experience muscle weakness, may see an improvement in muscle power with SAVT.MethodsPatients with mitochondrial disease started either a treatment (SAVT) or control phase (standing without vibration) for 12 weeks, then 12 weeks of washout, and then a 12-week cross-over. The main outcome measure was peak jump power (PJP). We compared this to a natural history cohort from clinic.ResultsSeven out of 13 patients completed at least 80% of their SAVT sessions and were analyzed. The ΔPJP after the control phase was −2.7 ± 1.7 W/kg (mean ± SEM), SAVT was +2.8 ± 0.6 W/kg (p < 0.05) and from the natural history cohort was −2.4 ± 0.8 W/kg/year.ConclusionsSAVT is well tolerated and may improve muscle power in mitochondrial disease patients.
Highlights
Side alternating vibration training (SAVT) is a mechanical oscillation using a vibrating platform that simulates exercise
SAVT was used in conjunction with exercise for training athletes in order to improve performance [11, 14], various neurologic disorders [15] and we have previously shown efficacy as a training regimen for both Duchenne muscular dystrophy [16, 17] and late-onset Pompe disease [18]
Each SAVT patient was diagnosed with a mitochondrial disorder as described in Table 2, data are not reported for patients in the natural history cohort
Summary
Side alternating vibration training (SAVT) is a mechanical oscillation using a vibrating platform that simulates exercise. We hypothesized that patients with mitochondrial myopathies, who experience muscle weakness, may see an improvement in muscle power with SAVT. Mitochondrial diseases are a diverse group of genetic diseases that can lead to impairment of the body’s ability to produce energy through oxidative phosphorylation. Myopathy is a common clinical feature of mitochondrial disease [3]. The most disabling feature of a mitochondrial disorder in neurologically competent children and adults is muscle weakness, loss of muscle function, exercise intolerance, and the eventual decline in ambulatory ability. For these patients, the ability to perform
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