Abstract
Characteristics of sickle ceil disease History Epidemiology and genetics Association with malaria Inheritance Clinical features Modifiers of clinical severity Pathophysiology Haemoglobinopathy Oxygen affinity Blood viscosity Cell membrane damage Micrncirculatory changes Molecular biology of sickle eelI anaemia Diagnosis Clinical examination Peripheral blood film and CBC Haemoglobin e]ectrophoresis I~rnergeney use of sodium metabisulphate preparation Neonatal diagnosis Prenatal diagnosis Treatment Supportive Specific therapies Augmentation of haemoglobin F Bone marrow transplantation Transfusion therapy Organization of Sickle Cell Centres in North America Management of general anaesthesia Preoperative considerations Technique of anaesthesia Sielde ceil crisis intraoperatively Controversies in anaesthetic management Preoperative use of blood transfusions The obstetric patient Neonates and infants The patient for open heart surgery
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