Sibling Similarity in Metabolic Syndrome: The Portuguese Sibling Study on Growth, Fitness, Lifestyle and Health.

Abstract

This study aims to estimate sibling resemblance in metabolic syndrome (MS) markers, and to investigate the associations of biological and behavioral characteristics with MS. The sample comprises 679 biological siblings (363 females; 316 males) aged 9-20years. MS markers included waist circumference (WC), high-density lipoprotein cholesterol (HDL-C), triglycerides (TRI), fasting glucose (GLU) and systolic blood pressure (SBP). Body mass index (BMI), biological maturation, muscular, and cardiorespiratory fitness were also assessed. Behavioral characteristics, including dietary intake and physical activity, were self-reported by questionnaire. Multilevel models were used, and sibling resemblance was estimated using the intraclass correlation (ρ). In general, same-sex siblings showed higher resemblance in MS markers than opposite-sex siblings. However, variability in sibling resemblance in MS markers was evident with the inclusion of covariates. Biological characteristics including age, BMI and maturity offset influenced all MS markers except for TRI. Importantly, behavioral characteristics diversely influenced MS markers: fruit and vegetables only influenced SBP, whereas physical activity affected HDL-C. Additionally, muscular fitness impacted significantly on MS Z-score, WC, SBP and GLU, whilst cardiorespiratory fitness only affected WC. In conclusion, biological and behavioral characteristics influenced the expression of MS markers. These results confirmed the importance of considering individual characteristics when designing individualized programs for diminishing the adverse effects of specific MS markers.