Abstract
Sialic acids (SAs) are typically found as terminal monosaccharides attached to cell surface glycoconjugates, which play crucial roles in various biological processes, and aberrant sialylation is closely associated with many diseases, particularly cancers. As SAs are overexpressed in tumor-associated glycoproteins, the recognition and specific binding of SA are crucial for monitoring, analyzing and controlling cancer cells, which would have a considerable impact on diagnostic and therapeutic application. However, both effective and selective recognition of SA on the cancer cell surface remains challenging. In recent years, SA-targeted biointerface materials have attracted great attention in various bio-applications, including cancer detection and imaging, drug delivery for cancer therapy and sialylated glycopeptide separation or enrichment. This review provides an overview of recent advances in SA-targeted biointerface materials and related bio-applications.
Highlights
Since the structure determination in the mid-1950s, important findings and detailed investigations have confirmed the significant role of sialic acids (SAs) in biology and medicine [1]
Through heterogeneous interaction have attracted considerable interests, due to their great potential to design and develop various devices. Such SA-targeted biointerface materials can achieve the facile detection by responding to SA-bearing glycoconjugates, even in cancer cells, in virtue of the optical, electrochemical or hydrophilic-hydrophobic properties of the material itself [22], which have presented broad potential applications related to cancers, such as biodetection and biosensing [23], controllable drug delivery and release [24], and bio-separation [25]
Figure (PBA)-terminated micelle coated with fructose by selective binding of overexpressed on the cancer (PBA)-terminated micelle coated with fructose by selective binding of SA overexpressed on the cancer cell surface
Summary
Since the structure determination in the mid-1950s, important findings and detailed investigations have confirmed the significant role of sialic acids (SAs) in biology and medicine [1]. Artificial biointerface materials, especially polymeric biointerfaces, capable of targeting and monitoring of SA through heterogeneous interaction have attracted considerable interests, due to their great potential to design and develop various devices Such SA-targeted biointerface materials can achieve the facile detection by responding to SA-bearing glycoconjugates, even in cancer cells, in virtue of the optical, electrochemical or hydrophilic-hydrophobic properties of the material itself [22], which have presented broad potential applications related to cancers, such as biodetection and biosensing [23], controllable drug delivery and release [24], and bio-separation [25]. Some existing challenges and outlooks for the future development of SA-targeted biointerface materials are presented
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