Shuyu Capsules Relieve Premenstrual Syndrome Depression by Reducing 5-HT3AR and 5-HT3BR Expression in the Rat Brain.

Fang Li,Dongmei Gao,Sheng Wei,Mingqi Qiao,Chunhong Song,Jizhen Feng,Jieqiong Wang

doi:10.1155/2016/7950781

Abstract

The effects of the Shuyu capsule on 5-HT3AR and 5-HT3BR expression in a rat model of premenstrual syndrome (PMS) depression and on 5-HT3AR and 5-HT3BR expression and hippocampal neuron 5-HT3 channel current were investigated, to elucidate its mechanism of action against PMS depression. PMS depression model rats were divided into depression and Shuyu- and fluoxetine-treated groups, which were compared to control rats for frontal lobe and hippocampal 5-HT3AR and 5-HT3BR expression and behavior. The depressed model rats displayed symptoms of depression, which were reduced in treated and normal control rats. Frontal lobe and hippocampal 5-HT3AR and 5-HT3BR levels were significantly higher in the model versus the control group and were significantly lower in the Shuyu group. As compared to control rats, the 5-HT3R channel current in the model group was significantly higher; the 5-HT3R channel current in hippocampal neurons treated with serum from Shuyu group rats was significantly lower than that in those treated with model group serum. Thus, PMS depression may be related to 5-HT3AR and 5-HT3BR expression and increased 5-HT3 channel current. Shuyu capsules rectified abnormal 5-HT3AR and 5-HT3BR expression and 5-HT3 channel current changes in a rat model; this finding may provide insight into treating PMS depression.

Highlights

Premenstrual syndrome (PMS), a disease commonly encountered in clinical gynecology, refers to a series of moods, mental and physical symptoms, and signs occurring in the premenstrual period of reproductive-aged women, including irritability, anxiety, nervousness, breast distention pain, and headache
It has been reported that monoamine neurotransmitters including 5-hydroxytryptamine 1A receptor, 5-hydroxytryptamine 2A receptor, 5-hydroxytryptamine 2C receptor, and 5-hydroxytryptamine 3 receptor are responsible for premenstrual syndromes [6,7,8,9,10,11]
Distributed in the central nervous system and peripheral nervous system, 5-HT3R influences the metabolism of neurotransmitters in brain tissues and influences receptor proteins related to mood, memory, and mental health conditions

Summary

Introduction

Premenstrual syndrome (PMS), a disease commonly encountered in clinical gynecology, refers to a series of moods, mental and physical symptoms, and signs occurring in the premenstrual period (luteal phase) of reproductive-aged women, including irritability, anxiety, nervousness, breast distention pain, and headache. Epidemiological surveys conducted worldwide have revealed that reproductive-aged women undergo one or more mood and physical PMS-related symptoms [3] that significantly influence their physical and mental health, as well as their quality of life. Distributed in the central nervous system and peripheral nervous system, 5-HT3R influences the metabolism of neurotransmitters in brain tissues (such as 5-HT, DA, CKK, and GABA) and influences receptor proteins related to mood, memory, and mental health conditions. In the central nervous system, 5-HT3 receptor subtypes are involved in the pathological processes of depression [12, 13], anxiety, and withdrawal symptoms, and Neural Plasticity

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