Abstract
Several posttranslational modifications of sHsps have been detected, including phosphorylation (Kim et al. 1983; Voorter et al. 1986), deamidation, acylation as well as mixed intermolecular disulfide formation, oxidation and glycation (for a review of the latter modifications, see Groenen et al. 1994). In this chapter, one of the most prominent modifications, the sHsp phosphorylation, the enzymes responsible for this modification as well as the possible functional implications will be reviewed in detail. However, it might well be that phosphorylation regulates sHsp structure and function in a complex interplay with some of the other modifications mentioned above.
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