Abstract
Data on the early (in-hospital) use of intravenous beta-blockade after ST-segment-elevation MI (STEMI) are inconclusive, despite proven benefits from long-term oral beta-blocker therapy that is initiated at hospital discharge. Now, in COMMIT, a double-blind trial cofunded by metoprolol’s manufacturer, researchers in China randomized 45,852 patients (mean age, 61) with suspected acute MI to receive immediate metoprolol (up to 15 mg IV, then 50 mg orally every 6 …
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