Abstract
Aim The aim of this observational study was to evaluate the effectiveness of a phytotherapic drug (Canephron N) in preventing urinary tract infection (UTI) in high-risk women undergoing urodynamic studies (UDS). Methods The study protocol was approved by the local institutional ethical committee. Adult women with at least one risk factor for acquiring UTI (defined as: age over 70, elevated postvoid residual urine>100 ml, recurrent UTI, pelvic organ prolapse (POP) ≥II in POP-Q scale, and neurogenic bladder) had received after UDS either a single oral dose of fosfomycin trometamol (FT) (3 grams) or a phytodrug containing centaury herb, lovage root, and rosemary leaves (5 ml taken orally three times daily for one week). All patients included in the study had no pyuria according to urine dipstick (nitrite and/or blood and/or leukocyte esterase) and negative urine culture (CFU < 103/ml) before UDS. Urine samples were also tested 7 days after UDS. Results Seventy-two high-risk participants completed the study. Seven days after urodynamic studies UTI symptoms, pyuria (nitrite and/or blood and/or leukocyte esterase) and bacteriuria with E. coli occurred in two patients (one (2.8%) in the FT and one (2.7%) in the phytodrug group, respectively). No statistical differences in UTI incidence were found between both treatment groups. We did not observe any additional adverse events in both groups. The major disadvantage of prophylaxis with the phytodrug as compared to FT was the necessity of continuing therapy for 7 days. Conclusion Prophylaxis of UTI with a phytodrug (Canephron N) may be considered a good alternative to antibiotic prophylaxis use after UDS in high-risk female patients.
Highlights
Urodynamic studies (UDS) are especially used to evaluate lower urinary tract function in patients with bladder outlet obstruction, urinary incontinence, and neurogenic bladder dysfunction [1]
In the randomized study conducted on 270 patients published by Hirakauva et al, antibiotic prophylaxis before UDS did not reduce the incidence of urinary tract infection (UTI) in women [5]
To the best of our knowledge, our study is the first, which compares the efficacy of phytodrug (Canephron N) to fosfomycin trometamol (3g) in preventing bacteriuria or symptomatic UTI after UDS
Summary
Urodynamic studies (UDS) are especially used to evaluate lower urinary tract function in patients with bladder outlet obstruction, urinary incontinence, and neurogenic bladder dysfunction [1]. The main value of prophylaxis is to decrease the risk of serious infection complications in patients after invasive procedures caused by the presence of bacteriuria. In the randomized study conducted on 270 patients published by Hirakauva et al, antibiotic prophylaxis before UDS did not reduce the incidence of UTI in women [5]. Latthe et al, based on the results of randomized controlled studies, noticed a 40% reduction in the risk of significant bacteriuria with the administration of prophylactic antibiotics of different dose, type, and duration after UDS [7]. It seems reasonable to reduce bacteriuria with antibiotic prophylaxis, because its rate correlates with the rate of infectious complications after invasive procedures [8]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
