Abstract
Human alpha-fetoprotein (HAFP), classified as a tumor-associated fetal protein, has been reported in the biomedical literature to display multiple molecular forms and complexes. Such forms have been demonstrated to include the following: 1) circulating serum full length HAFP; 2) non-secreted cell-bound cytoplasmic HAFP forms; 3) truncated mRNA expressed/translated forms largely found in cell culture supernatants; and 4) serum circulating inter-molecular complexed forms [1, 2]. Moreover, the native 70 kD circulating serum AFP form has long been employed in the clinic as a “gold standard” biomarker for hepatocellular carcinomas and germ cell tumors in addition to being a biomarker for fetal birth defects.
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