Should The Recommendation Of The American Association Of Clinical Endocrinologists For A Hemoglobin A1C Target Of 6.5% Be Modified? A Critical Reappraisal Of Recent Studies Of Intensive Glycemic Control

Abstract

In 2007, the American Association of Clinical Endocrinologists (AACE) published the AACE Medical Guidelines for Clinical Practice for the Management of Diabetes Mellitus (1). This evidence-based report adhered to the AACE Protocol for Standardized Production of Clinical Practice Guidelines (CPG) (2). Optimization of glycemic control remains based primarily on the measurement of hemoglobin A1c (A1C). The purpose of this commentary is to evaluate the current AACE recommendation for optimal glycemic control, an A1C value of 6.5%, in the context of clinical evidence published subsequent to the 2007 AACE CPG on diabetes, and this evaluation represents the opinions of the authors of this commentary.