Should SVGp12 Be Used for JC Polyomavirus Studies? Comment on Prezioso et al. COS-7 and SVGp12 Cellular Models to Study JCPyV Replication and MicroRNA Expression after Infection with Archetypal and Rearranged-NCCR Viral Strains. Viruses 2022, 14, 2070.

Stian Henriksen,Christine Hanssen Rinaldo

doi:10.3390/v15010089

Should SVGp12 Be Used for JC Polyomavirus Studies? Comment on Prezioso et al. COS-7 and SVGp12 Cellular Models to Study JCPyV Replication and MicroRNA Expression after Infection with Archetypal and Rearranged-NCCR Viral Strains. Viruses 2022, 14, 2070.

Stian Henriksen, Christine Hanssen Rinaldo

Open Access

https://doi.org/10.3390/v15010089

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Journal: Viruses	Publication Date: Dec 29, 2022
Citations: 2	License type: CC BY 4.0

Affiliation: University Hospital of North Norway, UiT The Arctic University of Norway

#JC Polyomavirus #JC Polyomavirus Strains + Show 8 more

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Abstract

A recent paper in Viruses investigates the impact of the JC polyomavirus (JCPyV) microRNA on the replication of different JCPyV strains. Unfortunately, one of the cell lines used, the human fetal glial cell line SVGp12, is productively infected by the closely related BK polyomavirus (BKPyV), which may confound results. Scientists need to take this into account and the potential pitfalls.

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