Abstract
BackgroundOral anticoagulation therapy is widely used to reduce the risks of thromboembolism. However, the therapy increases the risk of hemorrhage during the surgical procedures. The aim of this meta-analysis was to evaluate the bleeding risk of patients continuing or discontinuing oral anticoagulant therapy while undergoing dental extractions.MethodsSix electronic databases, including PubMed, Embase, Cochrane library, Web of Science, China Biology Medicine disc (CBM), and China National Knowledge Infrastructure (CNKI), were searched in March, 2016. Relevant articles were screened by two independent reviewers under our inclusion criteria. Quality was evaluated using the Cochrane Collaboration risk of bias tool. Meta-analyses were conducted with fixed and random effects models as appropriate.ResultsSix studies (with a total of 591 patients) were included in our meta-analysis. Our results showed that there was no significant difference in the bleeding risk between patients continuing or discontinuing oral anticoagulant therapy while undergoing dental extractions (risk ratio, 1.31; 95 % CI, 0.79, 2.14; P > 0.05). There was also no significant difference in bleeding risk 1 day (risk ratio, 0.91; 95 % CI, 0.35, 2.37; P > 0.05) and 7 days (risk ratio, 1.47; 95 % CI, 0.83, 2.59; P > 0.05) after the dental extraction.ConclusionUnder current studies and evidence, it appears that patients continuing oral anticoagulant therapy do not have an increased risk of bleeding after dental extractions compared to patients who discontinue oral anticoagulant therapy.
Highlights
Oral anticoagulation therapy is widely used to reduce the risks of thromboembolism
oral anticoagulant therapy (OAT) are frequently prescribed to elder patients, who have a higher demand for dental extraction caused by caries, periodontitis or other dental diseases
Database search A comprehensive search of the PubMed, EMBASE, Web of Science, Cochrane Library, China Biology Medicine disc (CBM), and China National Knowledge Infrastructure(CNKI) databases was conducted in March 2016
Summary
Oral anticoagulation therapy is widely used to reduce the risks of thromboembolism. The therapy increases the risk of hemorrhage during the surgical procedures. The aim of this meta-analysis was to evaluate the bleeding risk of patients continuing or discontinuing oral anticoagulant therapy while undergoing dental extractions. Millions of people receive oral anticoagulant therapy (OAT). Oral anticoagulation therapy is one of the most effective prophylactic medications for preventing life-threatening events [1, 2]. With the wide use of oral anticoagulant therapy (OAT), a major disadvantage of OAT that should receive more attention, is the increased risk of hemorrhage during surgical procedures. If OAT is continued, there is a high risk of bleeding, and if OAT is discontinued, the thromboembolic complications are potentially deadly
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