Abstract
ObjectivesThere are limited studies describing the association between ankylosing spondylitis (AS) and osteoporosis. We conducted a nationwide retrospective cohort study to investigate this epidemiologic evidence.MethodsData were obtained from the Taiwan National Health Insurance Research Database (NHIRD). Of 10,290 participants, 2,058 patients with AS and 8,232 patients without AS were enrolled from the NHIRD between 2000 to 2013. Cumulative incidences of osteoporosis were compared between 2 groups. Cox regression model was used to estimate the hazard ratio (HR) of developing osteoporosis after controlling for demographic and other co-morbidities, and subgroup analyses were conducted to examine the risk factors for osteoporosis in AS patients.ResultsThe incidence rate ratio (IRR) of osteoporosis in AS patients was 2.17 times higher than that non-AS group (95% confidence interval [CI], 1.83–2.57). The adjusted HRs of osteoporosis for AS patients after controlling for demographic characteristics and comorbid medical disorders was 1.99 (95% CI 1.68–2.36). Among AS group, after adjustment for major comorbidities, old age (≥65 years, HR 4.32, 95% CI 3.01–6.18), female sex (HR 2.48, 95% CI 1.87–3.28), dyslipidemia (HR 1.44, 95% CI 1.01–2.06) were risk factors associated with osteoporosis.ConclusionsThis cohort study demonstrated that patients with AS had a higher risk of developing osteoporosis, especially in those aged over 65, female sex and with dyslipidemia in this patient group.
Highlights
Ankylosing spondylitis (AS) is a chronic inflammatory disease involving the sacroiliac joints and spine; in some cases, the peripheral joints, entheses, and/or extraarticular structures may be involved [1]
The adjusted hazard ratio (HR) of osteoporosis for AS patients after controlling for demographic characteristics and comorbid medical disorders was 1.99
Among AS group, after adjustment for major comorbidities, old age ( 65 years, HR 4.32, 95% CI 3.01–6.18), female sex (HR 2.48, 95% CI 1.87– 3.28), dyslipidemia (HR 1.44, 95% CI 1.01–2.06) were risk factors associated with osteoporosis
Summary
Ankylosing spondylitis (AS) is a chronic inflammatory disease involving the sacroiliac joints and spine; in some cases, the peripheral joints, entheses, and/or extraarticular structures may be involved [1]. Osteoporosis is considered to be a musculoskeletal disease identified by a decreased bone mineral density (BMD); the disease has been shown to correlate with subsequent fragility fractures [6]. Evidence has shown that osteoporosis is relatively common in AS patients; the major pathophysiological mechanisms appear to be systemic inflammation and low BMD resulting from decreased daily physical activities caused by pain, stiffness, and/or ankyloses [7]. Numerous studies have demonstrated that, in AS patients, a low BMD and bone loss are observed within the first 10 years of disease [8,9,10]. Studies have indicated that patients with AS are at increased risk of osteoporosis and subsequent osteoporotic fractures due to bone fragility [11]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
