Abstract
The role of bone-targeted agents in the adjuvant treatment of early breast cancer has been debated for decades. A recent meta-analysis of individual patient data from 18,766 women provides compelling evidence supporting the use of these agents in postmenopausal women with early-stage breast cancer. Postmenopausal women who received a bisphosphonate had a significant reduction in breast cancer mortality (14.7 vs 18%; p = 0.002) and in overall survival (21.1 vs 23.5%; p = 0.005). Some questions remain such as; what bone-targeted agent is the best? What are the optimum doses, durations and schedules? Which patients benefit the most? The decision to include a bone-targeted agent should consider the absolute risk of distant recurrence and breast cancer mortality.
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