Abstract
University of Pittsburgh Department of Critical Care Medicine: Evidence-Based Medicine Journal Club, edited by Sachin Yende
Highlights
Citation Morelli A, Ertmer C, Westphal M, Rehberg S, Kampmeier T, Ligges S, Orecchioni A, D’Egidio A, D’Ippoliti F, Raffone C, Venditti M, Guarracino F, Girardis M, Tritapepe L, Pietropaoli P, Mebazaa A, Singer M: Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock
The median area under the curve (AUC) for the heart rate during the first 96 hours was −28/minute (interquartile range (IQR), −37 to −21) for the esmolol group versus −6/ minute (95% confidence interval, −14 to 0) for the control group with a mean reduction of 18/minute (P < 0.001)
Fluid requirements were reduced in the esmolol group: median AUC was 3,975 ml/24 hours (IQR, 3,663 to 4,200) versus 4,425 ml/24 hours (IQR, 4,038 to 4,775) for the control group (P < 0.001)
Summary
Citation Morelli A, Ertmer C, Westphal M, Rehberg S, Kampmeier T, Ligges S, Orecchioni A, D’Egidio A, D’Ippoliti F, Raffone C, Venditti M, Guarracino F, Girardis M, Tritapepe L, Pietropaoli P, Mebazaa A, Singer M: Effect of heart rate control with esmolol on hemodynamic and clinical outcomes in patients with septic shock. Background β-blocker therapy may control the heart rate and attenuate the deleterious effects of β-adrenergic receptor stimulation in septic shock. Β-blockers are not traditionally used for this condition and may worsen cardiovascular decompensation related through negative inotropic and hypotensive effects
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