Short-time oral contraceptive pills pretreatment for patients with high basal follicle stimulating horome concentrations in different age groups

Abstract

Objective To investigate the outcomes of in vitra fertilization (IVF-ET) cycles after short-time oral contraceptive pretreatment (OCP) combined with non-down regulation ovarian stimulation protocol in women with high basal follicle stimulating horome (FSH) in different age groups and its ovulation induction effect. Methods Retrospective statistic analysis had been done on the clinical data of IVF-ET women with high basal FSH who underwent IVF or intracytoplamic sperm injection (ICSI) in Reproductive Medicine Center of Henan Provincial People’s Hospital from September 2016 to December 2017, with 174 cycles totally. Patients were divided into age<40 year-old group and age≥40 year-old group according to patients’ age and then were further divided into OCP group and non-OCP group. Relavant indicators during the ovarian stimulation and cycle outcome were compared among these groups. Results Among the patients in age 0.05). Conclusions For the young patients with elevated FSH levels, the short-time OCP can effectively reduce FSH level at start day, and it combined with the non-down regulation ovarian stimulation protocol and frozen embryo transfer is a reasonable option to get good embryo implantation and clinical pregnancy rates. But it may lead to longer duration of Gn. For the older patients with high FSH level, the short-time OCP can reduce the FSH and LH levels at the Gn start day, as well as the LH and P levels on the HCG injection day. It may reduce the risk of premature LH surge. However, the duration and total dose of Gn may be increased and the indicators of ovarian stimulation and pregnancy outcome can not be improved in these older patients. Key words: In vitra fertilization; Basal follicle stimulating horome; Oral contraceptive pills; Short-time pretreatment