Short-term toxicity of methylphenylcarbinyl acetate in rats

Abstract

Groups of rats were given daily oral doses of 0 (control), 15, 50 or 150 mg methylphenylcarbinyl acetate/kg body weight for 13 wk. There were no effects on the rate of body-weight gain, although the food and water intakes were increased in the male rats given 150 mg/kg. The relative liver and kidney weights were increased in male rats given 50 or 150 mg/kg/day. There was an increased excretion of cells in the urine of male rats given 150 mg/kg for 6 wk. No histopathological changes were seen that could be related to treatment with methylphenylcarbinyl acetate. It was concluded that the no-untoward-effect level for methylphenylcarbinyl acetate when given to rats for 13 wk was 15 mg/kg.