Short-term outcome following treatment of intracranial aneurysms with pipeline embolization device

Abstract

Objective To present our preliminary experience and short-term safety and efficacy of pipeline embolization device (PED) for endovascular of intracranial aneurysms. Methods Six patients treated with PED in our hospital from February 2016 to June 2016 were chosen. Their clinical data and short-term safety and efficacy were retrospectively analyzed. Results Six patients with 6 intracranial aneurysms were treated during the study period. Mean aneurysm size was 18.3±9.2 mm. PED was technically successful in all aneurysms (100%). A total of 8 PEDs were used, and the mean number of devices per aneurysm was 1.3. Treatment was achieved with one single PED in 5 aneurysms, with 3 overlapping PEDs in one aneurysm. Adjunctive coiling was performed in 3 aneurysms. Retention of contrast agent in the tumor cavity was detected by immediate radiography: Kamran grade I was noted in 4 patients and grade II in 2 patients. No procedure-related complications occurred. Five patients achieved good clinical outcome (mRS score 0 in 2 patients, one in 3 patients and 3 in one patient). MRA was performed in 5 patients 3 months after surgery, indicating no arterial aneurysm residual and far-endvascular patency; and one of these 5 patients was performed DSA showing no arterial aneurysm relapse. Conclusions In our series, early results of the PED are encouraging. However, larger studies with longer follow-up duration are warranted to assess the safety and efficacy of PED for treating intracranial aneurysms. Key words: Intracranial aneurysm; Flow-diverter device; Pipeline embolization device