Short-term memory impairments in Alzheimer-type dementia: Evidence for separable impairments of articulatory rehearsal and long-term memory

Abstract

Two experiments are described which investigate the short-term memory deficits found in Alzheimer-type dementia. In the first experiment memory span for words of differing spoken duration is related to speech rate. Memory span was lower in subjects suffering from Alzheimer-type dementia than for normal elderly controls but in both cases a linear function related recall to speech rate for items of differing spoken durations. The functions for Alzheimer subjects had an equivalent slope (interpreted as reflecting a contribution from a sub-vocal rehearsal process) but a lower intercept (interpreted as reflecting a contribution from a long-term memory component). The second experiment investigated the effects of repeating supra-span lists of items in a serial recall task. As predicted the control subjects showed substantial increases in recall across trials associated with elevations of the speech rate/recall functions while the Alzheimer subjects showed very little benefit from repetition of the lists. We conclude that the verbal short-term memory deficit found in Alzheimer-type dementia has two components: a deficit in the rate of rehearsal and an impairment in the long-term memory component of short-term recall.