Short-term exposure to ozone and ECG abnormalities in China: A nationwide longitudinal study

Abstract

Ambient ozone (O3) pollution has been associated with an increased risk of cardiovascular diseases. However, few studies have addressed the effect of O3 exposure on electrocardiogram (ECG) abnormalities, a subclinical indicator of early damage to the cardiovascular system. This study aimed to examine the association between short-term exposure to O3 and ECG abnormalities. We included 102,027 visits of 47,290 participants over 40 years old who had a normal ECG at baseline and then visited again at least once from the China National Stroke Screening Survey (CNSSS). Short-term ozone exposure concentrations were measured as averages of maximum daily 8-h O3 concentrations over the two weeks prior to ECG measurements. The generalized estimation equations models were used to evaluate the association between O3 exposure and ECG abnormalities. For every 10 µg/m3 increment in short-term O3 concentration, the odds ratio of any ECG abnormality was 1.055 (95% confidence interval [CI] 1.045–1.064). For ECG-diagnosed cardiac arrhythmia, the odds ratio was 1.062 (95% CI 1.052–1.072). A nonlinear analysis showed a sublinear relationship between O3 exposure and risk for ECG abnormalities. The association between O3 exposure and ECG abnormalities varied by subpopulation. Our study provided new epidemiological evidence on the association between short-term O3 exposure and ECG abnormalities. There is an urgent need to control ambient O3 pollution to prevent cardiovascular events.