Abstract
Childhood obesity is becoming more prevalent; however, the influence of obesity or dieting during childhood on outcomes in adulthood is poorly understood. The aim of this study was to examine the effects of short-term calorie restriction (CR) and high-calorie feeding with high-fat or high-sucrose diets during early life on the development of glucose tolerance and diabetic nephropathy in later life of Otsuka Long-Evans Tokushima fatty (OLETF) rats. Neither high-calorie intake nor CR at 7–13 weeks of age affected glucose tolerance of 27-week-old OLETF rats. On the other hand, proteinuria was lower at 27 weeks of age in CR rats than in the other rats. These results suggest that short-term CR at a young age protects against the development of renal injury in later life. In contrast, short-term high-calorie intake or CR at a young age does not appear to affect glucose metabolism in later life.
Highlights
A massive increase in the prevalence of defective glucose metabolism, insulin resistance, and cardiovascular morbidity is anticipated in most developed countries [1,2,3]
It has been believed that the longer duration of diabetes in obese children is associated with an increased risk of cardiovascular events throughout their lifetime, it is unclear whether childhood obesity itself confers additional risk in later life
Shortterm high-fat feeding markedly increased the body weight in Otsuka Long-Evans Tokushima fatty (OLETF) rats at 13 weeks of age, the difference was abolished at 27 weeks of age
Summary
A massive increase in the prevalence of defective glucose metabolism, insulin resistance, and cardiovascular morbidity is anticipated in most developed countries [1,2,3]. Several studies have shown that body mass index (BMI) during childhood is associated with increased risk of early onset of type 2 diabetes and cardiovascular diseases [4, 5], and that the risk of dying by middle age is 2-3 times higher among obese adolescent girls than among those of normal weight [6]. It has been believed that the longer duration of diabetes in obese children is associated with an increased risk of cardiovascular events throughout their lifetime, it is unclear whether childhood obesity itself confers additional risk in later life. The effects of temporary calorie restriction at a young age on obesity-related problems, such as insulin resistance and diabetes, in later life are still unclear
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