Shorter interval to surgery after self-expanding metallic stent may result in better oncologic outcomes in colon cancer obstruction

Abstract

IntroductionColon cancer obstruction is one of the most serious conditions in colorectal surgery. However, the use of self-expanding metallic stent (SEMS) has made it possible to avoid emergency surgery and stoma creation, therefore enabling minimally invasive surgery and one-stage operation. In this study, we aimed to investigate whether there is an optimal interval from SEMS to surgery for the best long-term oncologic outcomes. MethodsObstructive colon cancer patients treated with SEMS insertion and received surgery were included in the study. Patient data were retrospectively reviewed in prospectively collected data. Using the ROC curve, the optimal interval to surgery after SEMS insertion was 10 days; the patients were divided into the early surgery group (≤ 10 days, ES) and the late surgery group (>10 days, LS). Factors contributing to the 5-year disease-free survival (DFS) and overall survival (OS) were analyzed. Results83 patients were included in this study. Eight patients (9.6%) had SEMS insertion failure, with 3 perforations and 5 failed expansions. There were no differences between the ES group and the LS group in terms of pathologic characteristics, incidence of stoma creation, and adjuvant chemotherapy. Twenty-six patients (31.3%) had recurrences; local (6), peritoneal seeding (8), liver (11), lung (7), bone (2), and abdominal wall metastasis (1). The 5-year DFS rate was significantly better in the ES group than the LS group (74.3% vs. 55.01%; p=0.0394). The 5-year OS was slightly better in the ES group than the LS group (76.11% vs. 58.75%; p=0.0901). In univariable analysis, the ES group showed a lower risk of recurrence than the LS group (OR: 0.447 [0.204-0.984], p=0.0455), but this was not reproduced in the multivariable analysis. ConclusionThis study has shown that the long-term oncologic outcomes were better in patients who received surgery after SEMS within 10 days. Hence, we propose with caution that elective surgery might be suggested to take place within 10 days from SEMS insertion for better oncologic outcomes.