Shortening of dioestrus in female dogs using cloprostenol sodium at different stages of dioestrus.

Deepak J,John Martin K D,John Martin K D, M P,Hiron M Harshan And K D John Martin C C

doi:10.51966/jvas.2021.52.4.321-324

Abstract

A study was conducted in 18 healthy, fertile, non-pregnant, dioestrous female dogs to evaluate the efficacy of PGF2? analogue (cloprostenol sodium) in shortening the dioestrus. Bitches that were diagnosed non-pregnant by trans-abdominal ultrasonography, on day 30 of breeding and their dioestrual stage confirmed by serum progesterone assay, were randomly allotted to three groups of six bitches each. Group I and II bitches were treated with cloprostenol sodium @ 2.5 µg/kg b. wt., subcutaneously, thrice at 48 h interval, beginning on day 30 and 45 of last breeding, respectively. Group III animals were assigned as control and were left untreated. Fifty days from first injection of cloprostenol, serum progesterone assay was carried out among the animals in Group I and II whereas the same was done among Group III bitches on day 90 after last breeding. Among Group I and II, mean serum progesterone concentrations were 0.93 ± 0.04 and 0.87 ± 0.01ng/ mL, respectively whereas the level was 1.72 ± 0.9 ng/mL among control group; highly significant difference (p<0.01) existed between control and treatment groups. The present study indicated that administration of PGF2? analogue during dioestrus enhances the pace of luteal regression among non-pregnant bitches.

Highlights

A study was conducted in 18 healthy, fertile, non-pregnant, dioestrous female dogs to evaluate the efficacy of PGF2α analogue in shortening the dioestrus
The present study focused on the efficiency of synthetic PGF2α analogue, cloprostenol sodium, when administered at mid- dioestrus and 15 days later, to shorten the period of prolonged dioestrus in non-pregnant bitches, so as to reduce the inter-oestrous interval (IEI) as well as risk of pathological conditions
Serum progesterone assay during middioestrus, on the day of selection

Summary

Introduction

A study was conducted in 18 healthy, fertile, non-pregnant, dioestrous female dogs to evaluate the efficacy of PGF2α analogue (cloprostenol sodium) in shortening the dioestrus. The present study focused on the efficiency of synthetic PGF2α analogue, cloprostenol sodium, when administered at mid- dioestrus and 15 days later, to shorten the period of prolonged dioestrus in non-pregnant bitches, so as to reduce the IEI as well as risk of pathological conditions. Progesterone assay was repeated 50 days from first injection of cloprostenol among the animals in Group I and II whereas the same was done on day 90 after last breeding, among Group III bitches.

Results

Conclusion