Short-term usage of three non-invasive ventilation interfaces causes progressive discomfort in healthy adults

Abstract

PurposeTo evaluate the effect of three different non-invasive ventilation (NIV) interfaces on the subjective discomfort of healthy individuals, and on a set of physiological parameters hypothesized to change in correspondence to discomfort.MethodsContinuous pressure NIV was applied to 20 subjects using Total Face, Nasal, and Face masks for 10 min each. Tidal volume (VT) and respiratory period (RP) were estimated from respiratory inductance plethysmography. Electrodermal activity was estimated from conductance signals. Heart rate variability was measured using the time-domain indices SDNN and RMSSD, and the respiratory sinus arrhythmia amplitude (RSAp). Parameters were referenced to 5-min rest periods at beginning and end of protocol. A Likert-like scale of subjective discomfort with the masks and the ventilation was applied after 1, 5, and 9 min using each mask.ResultsRP and VT increased with the three mask models. Whereas the mean heart rate and RSAp did not change, both SDNN and RMSSD increased during NIV with Nasal and Face masks. Spontaneous electrodermal activity fluctuations were less frequent during NIV than at rest, with significant differences for Total Face and Nasal masks. Discomfort with all masks increased from minutes 1 to 9, markedly in the Total Face mask, considered most uncomfortable by 11 subjects.ConclusionIn healthy subjects, the three masks resulted in similar respiratory responses to NIV. Correspondence between changes in physiological parameters and discomfort with NIV interface could not be detected, whereas self-report with the Likert-like scale identified progressive discomfort and the Total Face mask as the most uncomfortable interface.Supplementary InformationThe online version contains supplementary material available at 10.1007/s42600-020-00114-3.