Abstract
BackgroundThis study examined whether infants aged 0–3 months exhibited long-term effects of using a moisturizer skincare intervention and whether a short-term skin problem resulted in the subsequent development of food allergies or atopic dermatitis (AD) until the age of 2 years.MethodsThis study was a follow-up of a completed randomized control trial (RCT) of moisturizer skincare for infants aged 0–3 months. A self-reported questionnaire was mailed to the parents of children aged 1–2 years who had participated in the RCT. Data were analyzed using a Chi square test, by intention to treat analysis, and by multiple logistic regression.ResultsOf 155 infants, 22 (14.2%) and 28 (18.1%) had food allergies and AD/eczema until 2 years of age, respectively. No significant difference was seen in food allergies or AD between the group that received moisturizer skincare intervention and the control group. On the contrary, food allergies until 2 years of age were significantly associated with short-term (4–7 days) and long-term (more than 7 days) body skin problems occurring in the first 3 months of life, a family history of AD, and the time of starting complementary food. High value of face transepidermal water loss at 3 months of age was also associated with food allergies. Moreover, a short duration of severe diaper dermatitis during the first 3 months, a family history of AD, and being male were significantly associated with AD/eczema until the age of 2 years.ConclusionsAfter adjusting for family history of AD, a short-term skin problem in the first 3 months of life was significantly associated with the development of food allergies or AD/eczema until the age of 2 years. Prevention or prompt treatment of skin problems in newborns is essential for preventing future allergic diseases.Trial registration This was a follow-up study conducted 2 years after the completed RCT of a moisturizer skincare intervention for early infants, which was registered in the University Hospital Medical Information Network Clinical Trials Registry (UMIN000013260)
Highlights
This study examined whether infants aged 0–3 months exhibited long-term effects of using a moisturizer skincare intervention and whether a short-term skin problem resulted in the subsequent development of food allergies or atopic dermatitis (AD) until the age of 2 years
This mechanism is described by the “dual allergen exposure hypothesis” [1], which proposes that skin barrier dysfunction causes percutaneous sensitization of allergens before an infant commences complementary food
A number of previous studies have shown that skin barrier dysfunction, early onset atopic dermatitis (AD) and high transepidermal water loss (TEWL), can cause food allergies in children [2, 3]
Summary
This study examined whether infants aged 0–3 months exhibited long-term effects of using a moisturizer skincare intervention and whether a short-term skin problem resulted in the subsequent development of food allergies or atopic dermatitis (AD) until the age of 2 years. Skin conditions in early infants have received attention as a mechanism involved in the onset of infant allergies This mechanism is described by the “dual allergen exposure hypothesis” [1], which proposes that skin barrier dysfunction causes percutaneous sensitization of allergens before an infant commences complementary food. A number of previous studies have shown that skin barrier dysfunction, early onset atopic dermatitis (AD) and high transepidermal water loss (TEWL), can cause food allergies in children [2, 3]. Identifying and treating skin conditions, such as AD and other skin problems, in early infanthood is important for preventing childhood allergic diseases
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