Short-term plasticity of human spinal inhibitory circuits after isometric and isotonic ankle training

Abstract

The purpose of this study was to determine to what extent one session of isotonic and isometric ankle dorsi and plantar flexion training induces changes in the frequency-dependent depression of the soleus H-reflex. Further, adaptation of reciprocal Ia inhibition exerted from tibialis anterior flexor group I afferents on soleus motoneurons, and presynaptic inhibition of Ia afferent terminals induced by a conditioning afferent volley following stimulation of the antagonist nerve were established with subjects seated before and after training. The soleus H-reflexes evoked at the inter-stimulus intervals of 1, 2, 3, 5, and 8s were normalized to the mean amplitude of the H-reflex evoked every 10s. Conditioned H-reflexes were normalized to the associated control H-reflex evoked with subjects seated before and after training. Twenty-six subjects were randomly assigned to one or more of the 4 exercise groups. Isometric ankle dorsi flexion training decreased the reciprocal and presynaptic inhibition, while isotonic ankle dorsi flexion had no significant effects. Isotonic plantar flexion training decreased only the reciprocal inhibition, whilst isometric plantar flexion had no significant effects on the reciprocal or presynaptic inhibition. None of the training exercise protocols affected the amount of homosynaptic depression of the soleus H-reflex. Our findings support the notion that plastic changes of reciprocal and presynaptic inhibition due to exercise are transferrable to a resting state, and that homosynaptic depression remains unaltered after a single session of ankle training. Further research is needed to outline the time-course of plastic changes of spinal inhibitory mechanisms in humans.