Abstract
BackgroundToday the impairment of metabolism and obesity are being extensively investigated due to the significant increase of the prevalence of these diseases. There is scientific evidence that probiotics are beneficial for human health. Thus, the aim of the study was to investigate the effect of multiprobiotic “Symbiter acidophilic concentrated” on obesity parameters in the rats under experimental obesity.MethodsThe study was carried out on 60 newborn Wistar rats, divided into 3 groups, 20 animals in each (females – n = 10, males – n = 10): intact rats, monosodium glutamate (MSG-) and MSG + probiotic group. Rats of intact group were administered with saline (8 μl/g, subcutaneously (s.c.)). Newborns rats of MSG-group and MSG + probiotic group were injected with a solution of MSG (4.0 mg/g) s.c. at 2nd – 10th postnatal days. The MSG + probiotic group was treated with 140 mg/kg (1.4 × 1010 CFU/kg) of multiprobiotic “Symbiter”. MSG-group was treated with 2.5 ml/kg of water (per os) respectively. Administration was started at the age of 4 weeks just after wean and continued for 3 month intermittently alternating two-week course of introduction with two-week course of break.ResultsNeonatal treatment with MSG caused a stunted growth in both MSG-groups, which manifested with significantly smaller naso-anal length compared to adult intact rats. There was no significant difference in weight between intact and MSG-groups on 120th day. The adiponectin level in the serum of rats with MSG-induced obesity decreased by 2.43 times (p = 0.001) in males and 1.75 (p = 0.020) in females. Concentration of leptin in adipose tissue were significantly higher by 45.9% (p = 0.019) and 61.2% (p = 0.009) respectively in males and females compared to intact rats. Our study has indicated that daily oral administration of multiprobiotic to neonatal MSG-treated rats by 2-week courses led to significant reduce of total body and VAT weight with subsequent improvement in insulin sensitivity and prevention of non-alcoholic fatty liver (NAFLD) development.ConclusionsThese results have shown that periodic treatment with multiprobiotic prevents the MSG-induced obesity and NAFLD development.
Highlights
Today the impairment of metabolism and obesity are being extensively investigated due to the significant increase of the prevalence of these diseases
In our previous work we have shown that probiotics mixture of lyophilized strains Lactobacillus casei IMVB-7280, Bifidobacterium animalis VKL and Bifidobacterium animalis VKB at least partially prevent the monosodium glutamate (MSG-)induced obesity in rats [20]
Given the above the aim of our work was to investigate the prophylactic influence of short periodical courses of the alive multiprobiotic administration on the obesity and non-alcoholic fatty liver development (NAFLD) development induced by the neonatal MSG treatment in 4-month male and female rats
Summary
Today the impairment of metabolism and obesity are being extensively investigated due to the significant increase of the prevalence of these diseases. Obesity has dramatically increased during the past decades and has reached epidemic proportions in both developed and developing countries [1,2]. In current scientific literature there are a lot of studies that confirm beneficial effects of probiotics on human organism. The gut microbiota has been recently proposed to be an environmental factor involved in the control of body weight and energy homeostasis [13,14,15,16,17] This “exteriorized organ” contributes to human homeostasis via multiple metabolic functions and diverse control mechanisms
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